ABSTRACT
The aim of this current study was to evaluate phytochemistry along with pharmacological activities of the whole plant of Rumex maritimus L. (Family: Polygonaceae). Phytochemical analysis of the extract of R. maritimus indicates the presence of Reducing Sugar, Glycoside, Gum, Tannin and Alkaloid type compounds and the pharmacological attention of these compounds prompted us to check R. maritimus for possible anti-oxidant, antimicrobial and antidiarrheal activities in a dose dependent manner. The dried plants were subjected to successive extraction with methanol and the extract was used to investigate the activities. The extract of plants produced good diarrheal inhibition in castor oil induced diarrhea in mice (250mg/kg and 500mg/kg body weight) which was comparable to the standard drug Loperamide at the dose of 3 mg/kg of body weight. The alcoholic extract was showed anti-bacterial activity against the tested microorganisms (both gram positive as well as negative bacteria). This study reveals the potent anti-oxidant activity that is (IC50~80 μg/ml) to that of standard drug ascorbic acid (IC50 about ~7 μg/ml) in-vitro when tested in 1, 1-Diphenyl-2-picrylhydrazyl (DPPH) scavenging method. The obtained results provide a support for the use of this plant in traditional medicine and its further investigation.
ABSTRACT
The aim of the study was to develop a formulation of Ticagrelor 90 mg tablets that is equivalent to the reference product using similar excipients to match the in-vitro dissolution profile. A compressed coated tablet was formulated consisting of Ticagrelor and excipients conforming to the USP/BP monograph and below maximum amount allowed per unit dose. The physical characteristics of powder blends were evaluated for bulk density, tapped density, compressibility index, hausner ratio, angle of repose and moisture content. The compressed core and coated tablets were evaluated for thickness, hardness, weight variation, friability, disintegration, dissolution, drug content and stability. The powder blends for all formulations showed satisfactory bulk density, tapped density, compressibility index, hausner ratio, angle of repose and moisture content. All the core and coated tablets showed acceptable pharmaco-technical properties in terms of thickness, hardness, weight variation, friability, disintegration. Dissolution performances were varied depending on the composition of matrix tablet. Finally a formulation batch B05 consisting of Ticagrelor (34.61%), mannitol (61.15%), sodium starch glycolate (2.69%), hypromellose (HPMC-2910, 5cps) (0.77%), purified talc (0.38%), magnesium stearate (0.38%) and opadry grey (21k57558) (2%) showed maximum similarity with the reference product. Using this formulation a pharmaceutical will be able to met regulatory compliance.